Anaerobic metabolism was studied in erythrocytes of the bivalve Scapharca inaequivalvis and compared with other tissue cells. In all cells aspartate reserves are utilized and alanine and succinate accumulate. Erythrocytes are distinct from other tissues as regards the anaerobic energy supply. Phosphoarginine is not stored in the erythrocytes. The low glycogen content and the absence of glycogen phosphorylase indicate that the former cannot serve as anaerobic fuel. During 24 hr of anaerobiosis the energy charge in the erythrocytes decreased from 0.83 to 0.64.
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