The laboratory for Molecular Biodiscovery is a zebrafish-based platform for small-molecule drug discovery for CNS disorders and the evaluation of drug-induced organ toxicities. The group has experience in high-throughput behavioral and seizure assays, whole mount in situ hybridisation, EEG whole brain recording, transgenic zebrafish lines, antisense knockdowns, fluorescence microscopy and cryotome sectioning.
The marine component includes the zebrafish-based discovery of antiseizure compounds from the North Sea and Red Sea.
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Standard name: Moleculaire Bio-ontdekking
Parent institute: KU Leuven; Departement Farmaceutische en Farmacologische Wetenschappen (KULeuven), more
Type: Scientific
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1 Director: Head of the department 2 Marine scientist: Works in this research group and acts as (co-)author in at least one marine publication in the last 5 years. 3 Specialized personnel: Provides administrative or technical support to marine scientific research.
( 6 peer reviewed ) split up filter
 Kokkini, M.; Oves-Costales, D.; Sanchez, P.; Melguizo, A.; Mackenzie, T.A.; Perez-Bonilla, M.; Martin, J.; Giusti, A.; de Witte, P.; Vicente, F.; Genilloud, O.; Reyes, F. (2023). New phocoenamicin and maklamicin analogues from cultures of three marine-derived Micromonospora strains. Mar. Drugs 21(8): 443. https://dx.doi.org/10.3390/md21080443, more- Copmans, D.; Kildgaard, S.; Roux, E.; Partoens, M.; Steurs, G.; Wang, X.; De Borggraeve, W.M.; Esguerra, C.V.; Crawford, A.D.; Larsen, T.O.; de Witte, P.A.M. (2022). From the North Sea to drug repurposing, the antiseizure activity of halimide and plinabulin. Pharmaceuticals 15(2): 247. https://dx.doi.org/10.3390/ph15020247, more
- Copmans, D.; Kildgaard, S.; Rasmussen, S.A.; Ślęzak, M.; Dirkx, N.; Partoens, M.; Esguerra, C.V.; Crawford, A.D.; Larsen, T.O.; de Witte, P.A.M. (2019). Zebrafish-based discovery of antiseizure compounds from the North Sea: isoquinoline alkaloids TMC-120A and TMC-120B. Mar. Drugs 17(11): 607. https://dx.doi.org/10.3390/md17110607, more
- Copmans, D.; Rateb, M.; Tabudravu, J.N.; Perez-Bonilla, M.; Dirkx, N.; Vallorani, R.; Diaz, C.; del Palacio, J.P.; Smith, A.J.; Ebel, R.; Reyes, F.; Jaspars, M.; de Witte, P.A.M. (2018). Zebrafish-based discovery of antiseizure compounds from the Red Sea: pseurotin A2 and Azaspirofuran A. ACS Chemical Neuroscience 9(7): 1652-1662. https://dx.doi.org/10.1021/acschemneuro.8b00060, more
- Sonnenschein, E.C.; Stierhof, M.; Goralczyk, S.; Vabre, F.M.; Pellissier, L.; Hanssen, K.O.; de la Cruz, M.; Diaz, C.; de Witte, P.; Copmans, D.; Andersen, J.H.; Hansen, E.; Tormo, J.R.; Ebel, R.; Milne, B.F.; Deng, H.; Gram, L.; Jaspars, M.; Tabudravu, J.N. (2017). Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040. Tetrahedron 73(18): 2633-2637. https://dx.doi.org/10.1016/j.tet.2017.03.051, more
- Jaspars, M.; De Pascale, D.; Andersen, J.H.; Reyes, F.; Crawford, A.D.; Ianora, A. (2016). The marine biodiscovery pipeline and ocean medicines of tomorrow. J. Mar. Biol. Ass. U.K. 96(1): 151-158. https://hdl.handle.net/10.1017/s0025315415002106, more
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