IMIS - Marine Research Groups | Compendium Coast and Sea

IMIS - Marine Research Groups

[ report an error in this record ]basket (0): add | show Print this page
Involvement of cyclic nucleotides and IP3 in the regulation of luminescence in the brittlestar Amphipholis squamata (Echinodermata)
De Bremaeker, N.; Dewael, Y.; Baguet, F.; Mallefet, J. (2000). Involvement of cyclic nucleotides and IP3 in the regulation of luminescence in the brittlestar Amphipholis squamata (Echinodermata). Luminescence 15(3): 159-163. https://dx.doi.org/10.1002/1522-7243(200005/06)15:3<159::AID-BIO581>3.0.CO;2-P
In: Luminescence. Wiley: Chichester, Sussex, UK. ISSN 1522-7235; e-ISSN 1522-7243, more
Peer reviewed article  
Available in  Authors 
Keyword
    Marine/Coastal
Authors  Top 
  • De Bremaeker, N.
  • Dewael, Y.
  • Baguet, F., more
  • Mallefet, J., more
Abstract
    We investigated the effects of cyclic nucleotides (cGMP, cAMP) and the phosphoinositide IP3 on the luminescence of the ophiuroid Amphipholis squamata. The cGMP analogue, dibutyryl-cGMP, and the guanylate cyclase activator, sodium nitroprusside, had no effect on the luminescence. The cAMP analogue, dibutyryl-cAMP, and the adenylate cyclase activator, forskolin, triggered luminescence. Moreover, the adenylate cyclase inhibitor, MDL-12330A, significantly reduced ACh-induced luminescence. The phospholipase C inhibitor, U-73122, also significantly reduced ACh-induced luminescence. The results suggest that ACh-induced luminescence is mediated by both cAMP and IP3 pathways but not by cGMP. The effects of calcium-free ASW confirmed this hypothesis. A hypothetical scheme of the transduction mechanisms involved in the intracellular control of luminescence is presented.
All data in the Integrated Marine Information System (IMIS) is subject to the VLIZ privacy policy Top | Authors